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Symbios Technologies is a world-leading developer of aqueous plasma technology for generating nitrogen fertilizer from air, water, and electricity. The privately held company was founded in January 2008 and is headquartered in Fort Collins, Colorado at the Colorado State University (CSU) Research Innovation Center within the Infectious Disease Research Center (IDRC) on the CSU Foothills Campus. Initial technology development and vetting was performed at the University of Wisconsin, Colorado State University, and the U.S. Naval Research Laboratory. The Tubular Plasma Reactor (TPR) was developed by Symbios under a Phase II Small Business and Innovation Research (SBIR) grant support from the U.S. National Science Foundation (NSF), National Institute of Health (NIH), and strategic funding with previous funding including the U.S. Department of Energy (DOE) and other partners.

Overall, Symbios Technologies is commercializing its disruptive advanced low-cost aqueous plasma oxidation technology, the Symbios Tubular Plasma Reactor4000™ (TPR4000™), to improve production economics and sustainability in the nitrogen fertilizer industry.